01426nas a2200325   4500000000100000008004100001260001300042653001500055653001500070653002500085653001000110653002100120653001100141653001800152653001100170653002300181653001200204653000900216100001300225700001700238700001300255700001400268245006200282856005100344300001000395490000700405050001600412520065800428022001401086       2007                            d  c2007 Sep10aAdolescent10aBiomarkers10aCase-Control Studies10aChild10aChild, Preschool10aFemale10aGlucuronidase10aHumans10aLeprostatic Agents10aleprosy10aMale1 aNandan D1 aVenkatesan K1 aKatoch K1 aDayal R S00aSerum beta-glucuronidase levels in children with leprosy.  uhttps://leprosyreview.org/article/78/3/24-3247  a243-70 v78  aNANDAN 20073 a<p>A study was undertaken to find out the usefulness of determining the circulating levels of beta-glucuronidase, a lysosomal enzyme in leprosy affected children of less than 15 years of age. The serum enzyme levels were significantly higher in BB/BL patients compared to healthy control children as well as children with skin diseases other than leprosy. Treatment with Multidrug regimen advocated by WHO for multi/paucibacillary leprosy resulted in a significant fall in the serum enzyme levels in BB and BL cases. The findings suggest that serum beta-glucuronidase may be a useful parameter for the activity and extent of pathogenesis in leprosy.</p>  a0305-7518