01076nas a2200265   4500000000100000008004100001260001300042653002600055653001500081653003100096653002100127653001100148653003200159653001300191653002500204100001300229700001300242700001400255700001200269245012800281300001000409490000700419520037000426022001400796       2008                            d  c2008 Feb10aAnti-Infective Agents10aDNA gyrase10aDrug Resistance, Bacterial10aFluoroquinolones10aHumans10aMicrobial Sensitivity Tests10aMutation10aMycobacterium leprae1 aMatrat S1 aCambau E1 aJarlier V1 aAubry A00aAre all the DNA gyrase mutations found in Mycobacterium leprae clinical strains involved in resistance to fluoroquinolones?  a745-70 v523 a<p>Mycobacterium leprae DNA gyrases carrying various mutations, previously described in clinical strains, were investigated for quinolone susceptibility by inhibition of supercoiling and DNA cleavage promotion. We demonstrated that the gyrA mutations leading to G89C or A91V confer fluoroquinolone resistance whereas the gyrB mutation leading to D205N does not.</p>  a0066-4804