01777nas a2200313   4500000000100000008004100001260001300042653001200055653001600067653002300083653001800106653001200124653000900136653001500145653002500160100001200185700001600197700001100213700001400224700001500238700002100253245015500274856005900429300001100488490000700499050003200506520091100538022001401449       1991                            d  c1991 Sep10aAnimals10aBCG Vaccine10aBacterial Vaccines10aKidney Cortex10aleprosy10aMice10aMicrovilli10aMycobacterium leprae1 aKohli M1 aGanguly N K1 aKaur S1 aChugh K S1 aSharma V K1 aBhushnurmath S R00aDoes Convit vaccine (BCG + Mycobacterium leprae) afford protection against biochemical changes in renal brush border membrane in experimental leprosy?  uhttp://leprev.ilsl.br/pdfs/1991/v62n3/pdf/v62n3a04.pdf  a269-750 v62  aInfolep Library - available3 a<p>Renal functional status in Mycobacterium leprae infected mice can be best studied by examining the enzymatic status of brush border membrane vesicles from proximal convoluted tubule. The role of vaccination in modulation of the renal status brought by the disease has been studied using this technique. The characteristic marker enzymes of renal brush border membrane--namely alkaline phosphatase, leucine aminopeptidase and gamma-glutamyl transpeptidase decreased significantly (p less than 0.01) in due course in M. leprae infection over a period of 9 months. The combined vaccine (BCG + M. leprae) may have a protective effect on renal abnormalities only in the initial stages of infection as indicated by a significant rise in enzymatic levels. However, no significant (p greater than 0.05) protective effect of vaccine was found in a more advanced disease state after 9 months in infected mice.</p>  a0305-7518