01582nas a2200301   4500000000100000008004100001260001300042653001600055653002300071653001100094653001200105653002100117653001600138100001000154700001500164700001200179700001200191700001800203700001200221700001300233245006400246856005900310300001100369490000700380050003200387520084700419022001401266       1991                            d  c1991 Dec10aBone Marrow10aHistocytochemistry10aHumans10aleprosy10aLipid Metabolism10aMacrophages1 aSen R1 aSehgal P K1 aDixit V1 aSingh U1 aChaudhary S D1 aSikka R1 aJain V K00aLipid-laden macrophages in bone marrow of leprosy patients.  uhttp://leprev.ilsl.br/pdfs/1991/v62n4/pdf/v62n4a03.pdf  a374-800 v62  aInfolep Library - available3 a<p>While conducting a study to observe bone marrow cytomorphological changes in multibacillary leprosy, lipid laden macrophages as seen in sphingolipidoses were noted. The present study was planned to observe the occurrence and morphological characterization of these macrophages in various types of leprosy. Bone marrow records from 48 cases of paucibacillary and 72 cases of multibacillary leprosy were analysed. The macrophages accounting at the most for 3.5% of marrow cells were observed in 5 cases of paucibacillary and 43 cases of multibacillary leprosy with a maximum incidence being observed in patients with ENL (16/17). The lipid present in the cytoplasm of these cells could be derived from the lipid of the cell wall of Mycobacterium leprae. To the best of our knowledge, these cells have not been reported in leprosy so far.</p>  a0305-7518