02837nas a2200469   4500000000100000008004100001260001300042653001000055653000900065653002200074653001100096653001200107653002100119653002100140653002300161653002500184653002800209653002200237653001100259653001100270653002300281653002500304653000900329653001600338653001000354653001900364653001600383100002200399700001800421700001500439700001800454700001200472700001400484700001600498700001500514700001600529245012500545300001000670490000700680520166600687022001402353       2009                            d  c2009 Nov10aAdult10aAged10aAged, 80 and over10aBrazil10aCandida10aCandida albicans10aCandida glabrata10aCandida tropicalis10aCase-Control Studies10aColony Count, Microbial10aDrug Combinations10aFemale10aHumans10aLeprostatic Agents10aLeprosy, lepromatous10aMale10aMiddle Aged10aMouth10aMouth Diseases10aYoung Adult1 aAraújo Navas EAF1 aInocêncio AC1 aAlmeida JD1 aBack-Brito GN1 aMota AJ1 aJorge AOC1 aQuerido SMR1 aBalducci I1 aKoga-Ito CY00aOral distribution of Candida species and presence of oral lesions in Brazilian leprosy patients under multidrug therapy.  a764-70 v383 a<p><b>OBJECTIVE: </b>The aim of this study was to evaluate the prevalence of Candida spp. and presence of oral lesions in Brazilian leprosy patients under multidrug therapy (MDT).</p><p><b>METHODS: </b>Thirty-eight individuals (18 males and 20 females, median age 53 years) clinically and microbiologically diagnosed as leprosy (lepromatous variant), and under MDT for at least 45 days were studied. The control group constituted by 38 healthy individuals (median age 53.5), matched to the test group in relation to age, gender and oral conditions. Oral rinses were collected and the Candida identification was performed by phenotypic tests. The existence of Candida dubliniensis among the isolates was analyzed using a validated multiplex PCR assay. Twenty-nine leprosy patients were examined intra-orally for the presence of lesions. Data were analyzed by z- and Mann-Whitney tests (alpha = 5%).</p><p><b>RESULTS: </b>Yeast carriage rate between leprosy patients (65.8%) and controls (47.4%) was similar (P = 0.099), and no significant difference between yeast counts was observed (P = 0.1004). Candida albicans was the most frequently isolated species in both groups. In the leprosy group, Candida tropicalis and Candida parapsilosis were also identified. In the control group, we additionally identified Candida tropicalis, Candida glabrata and Candida kefyr. Candida dubliniensis was not detected. No leprosy-related oral lesion was registered.</p><p><b>CONCLUSION: </b>Within the limits of the study, we concluded that Brazilian leprosy patients under MDT showed similar levels of carriage and Candida species distribution in relation to the controls.</p>  a1600-0714