01822nas a2200397   4500000000100000008004100001260001600042653003000058653003200088653003100120653002000151653003800171653001400209653001100223653001200234653002500246653001200271100001300283700001200296700001200308700001500320700001200335700001300347700001000360700001200370700001300382700001100395700001400406245011700420856006700537300001200604490000800616050002000624520076600644022001401410       2007                            d  c2007 Oct 1510aCation Transport Proteins10aChromosomes, Human, Pair 1710aChromosomes, Human, Pair 210aGenetic Linkage10aGenetic Predisposition to Disease10aGranuloma10aHumans10aleprosy10aMycobacterium leprae10aVietnam1 aRanque B1 aAlter A1 aMira MT1 aVan Thuc N1 aThai VH1 aHuong NT1 aBa NN1 aKhoa PX1 aSchurr E1 aAbel L1 aAlcaïs A00aGenomewide linkage analysis of the granulomatous mitsuda reaction implicates chromosomal regions 2q35 and 17q21.  uhttp://jid.oxfordjournals.org/content/196/8/1248.full.pdf+html  a1248-520 v196  aRANQUA 2007.pdf3 a<p>The Mitsuda reaction, a delayed granulomatous skin reaction elicited by the intradermal injection of heat-killed Mycobacterium leprae, is an in vivo test reflecting the ability to generate an immune granuloma after sensitization by diverse mycobacterial infections. Accumulating evidence for the genetic control of the Mitsuda reaction has been reported. We performed a genomewide linkage scan for the quantitative Mitsuda reaction in 19 large families from Vietnam with a history of leprosy (114 offspring). Suggestive linkage was found at chromosomal regions 2q35 (P = 9 x 10(-4) at the SLC11A1 locus) and 17q21-25 (P = 8 x 10(-4)). Interestingly, these 2 regions have been previously linked to mycobacterial infection and other granulomatous diseases.</p>  a0022-1899