02281nas a2200457   4500000000100000008004100001260001300042653001500055653001000070653001000080653001900090653001900109653002100128653001100149653001100160653001200171653000900183653001600192653001600208653002500224653001400249653003000263653001300293653001700306653001700323100001300340700001400353700001400367700001300381700001500394700001300409700001600422700001300438700001800451700001500469245016500484300001100649490000700660520114200667022001401809       2007                            d  c2007 Nov10aAdolescent10aAdult10aAging10aCohort Studies10aDNA, Bacterial10aErythema Nodosum10aFemale10aHumans10aleprosy10aMale10aMiddle Aged10aMinocycline10aMycobacterium leprae10aOfloxacin10apolymerase chain reaction10aRifampin10aRisk Factors10aTime Factors1 aSousa AL1 aStefani M1 aPereira G1 aCosta MB1 aRebello PF1 aGomes MK1 aNarahashi K1 aGillis T1 aKrahenbuhl JL1 aMartelli C00aMycobacterium leprae DNA associated with type 1 reactions in single lesion paucibacillary leprosy treated with single dose rifampin, ofloxacin, and minocycline.  a829-330 v773 a<p>Leprosy affects skin and peripheral nerves, and acute inflammatory type 1 reactions (reversal reaction) can cause neurologic impairment and disabilities. Single skin lesion paucibacillary leprosy volunteers (N = 135) recruited in three Brazilian endemic regions, treated with single-dose rifampin, ofloxacin, and minocycline (ROM), were monitored for 3 years. Poor outcome was defined as type 1 reactions with or without neuritis. IgM anti-phenolic glycolipid I, histopathology, Mitsuda test, and Mycobacterium leprae DNA polymerase chain reaction (ML-PCR) were performed at baseline. chi(2) test, Kaplan-Meir curves, and Cox proportional hazards were applied. The majority of volunteers were adults with a mean age of 30.5 +/- 15.4 years; 44.4% were ML-PCR positive. During follow-up, 14.8% of the patients had a poor clinical outcome, classified as a type 1 reaction. Older age (> or = 40 years), ML-PCR positivity, and lesion size > 5 cm were associated with increased risk. In multivariate analysis, age (> or = 40 years) and ML-PCR positivity remained baseline predictors of type 1 reaction among monolesion leprosy patients.</p>  a1476-1645