01325nas a2200301   4500000000100000008004100001260000900042653001200051653001400063653002700077653003000104653002700134653001200161653000900173653002100182653001600203653001500219653001600234653002100250653001300271653002200284100001500306700001700321245010400338300000900442520055800451022001401009       2007                            d  c200710aAnimals10aArmoracia10aDisease Models, Animal10aDrug Therapy, Combination10aHorseradish Peroxidase10aleprosy10aMice10aMice, Inbred CBA10aNeutrophils10aPeroxidase10aPlant Roots10aPotassium Iodide10aRifampin10aTreatment Outcome1 aMaslov A K1 aKhivrina S A00a[Prospects for leprosy treatment via complexation of rifampicin witH iodide and horse-radish root].  a25-73 a<p>A model of leprosy was used to study the therapeutic effect of horse-radish root (HRR) containing peroxidase in combination with rifampicin (RFP) and potassium iodide (PI) as compared to routine combined therapy with RFP and diaminodiphenylsulfonum. Therapy with HRR and iodide showed the best antimicrobial effect than the routine combined therapy. A combination of RFP, HRR, and PI increased the activity of neutrophilic myeliperoxidase produced an anti-inflammatory activity and caused no persistent anemia or toxic effect on the murine liver.</p>  a1728-2993