01637nas a2200337   4500000000100000008004100001260001700042653001000059653004200069653004200111653002500153653001900178653001100197653002100208653002300229653002400252653002500276653000900301653000900310653001300319100001400332700001100346700001400357700001400371245008500385300001000470490000700480050001700487520078100504022001401285       2007                            d  c2007 Jul-Aug10aAdult10aAIDS-Related Opportunistic Infections10aAntiretroviral Therapy, Highly Active10aCD4 Lymphocyte Count10aHIV Infections10aHumans10aHypersensitivity10aLeprostatic Agents10aLeprosy, Borderline10aLeprosy, Tuberculoid10aMale10aSkin10aSyndrome1 aKharkar V1 aBhor U1 aMahajan S1 aKhopkar U00aType I lepra reaction presenting as immune reconstitution inflammatory syndrome.  a253-60 v73  aKHARKAR 20073 a<p>Immune reconstitution inflammatory syndrome (IRIS) is an unusual inflammatory reaction due to infectious and non-infectious causes occurring in human Immunodeficiency virus (HIV)-infected patients. IRIS occurs after the initiation of antiretroviral therapy. There are no reports of type I lepra reaction due to IRIS in published literature from India. We report two cases of HIV-infected males who presented with borderline tuberculoid leprosy in type 1 reaction after the initiation of highly active antiretroviral treatment (HAART). Case 1 presented with multiple, tender, erythematous and hypoesthetic plaques on the trunk and extremities after 3 months of antiretroviral therapy. In case 2, type I lepra reaction was observed 2 months after the initiation of HAART.</p>  a0973-3922