01588nas a2200313   4500000000100000008004100001260001300042653000900055653003000064653001600094653001100110653002300121653002500144653000900169653001600178653002500194653000900219100001400228700001500242700001300257700001600270700001200286700001500298245005800313300001000371490000700381520087200388022001401260       2007                            d  c2007 Sep10aAged10aDrug Therapy, Combination10aHistiocytes10aHumans10aLeprostatic Agents10aLeprosy, lepromatous10aMale10aMiddle Aged10aMycobacterium leprae10aSkin1 aPereyra S1 aDanielo CA1 aPonssa G1 aConsigli JE1 aPapa MB1 aGhirardi G00aWade's histoid leprosy: three clinical presentations.  a944-60 v463 a<p>Wade's histoid leprosy is a rare form of multibacillary leprosy with distinctive characteristics which were first described in patients treated with a short course of sulfones. Wade's histoid leprosy may occur as a relapse, in the setting of sulfone resistance, or may present de novo. We report the clinical, histologic, immunologic, and bacteriologic features of three adult male patients with this rare variant of lepromatous leprosy as the initial presentation of the disease, observed in the Dermatology Department of Hospital Córdoba, Córdoba, Argentina between 1999 and 2003. Two of the three patients were from an endemic leprosy area. All patients presented with a number of erythematous to brownish gray, firm but elastic nodules involving mainly the extremities, which responded to treatment for multibacillary leprosy without reactional episodes.</p>  a0011-9059