01752nas a2200409   4500000000100000008004100001260001300042653002600055653003800081653001100119653001000130653001200140653002200152653002500174653003200199653002000231100001200251700001200263700001000275700001500285700001600300700001000316700001600326700001300342700001400355700001100369700001200380700001100392700001300403245008400416856007600500300001000576490000800586050001500594520071900609022001401328       2007                            d  c2007 Jul10aAntibodies, Bacterial10aEnzyme-Linked Immunosorbent Assay10aHumans10aJapan10aleprosy10aMembrane Proteins10aMycobacterium leprae10aSensitivity and Specificity10aSerologic Tests1 aMaeda Y1 aMukai T1 aKai M1 aFukutomi Y1 aNomaguchi H1 aAbe C1 aKobayashi K1 aKitada S1 aMaekura R1 aYano I1 aIshii N1 aMori T1 aMakino M00aEvaluation of major membrane protein-II as a tool for serodiagnosis of leprosy.  uhttp://onlinelibrary.wiley.com/doi/10.1111/j.1574-6968.2007.00754.x/pdf  a202-50 v272  aMAEDA 20073 a<p>As serodiagnosis is the easiest way of diagnosing a disease, the utility of Mycobacterium leprae-derived major membrane protein-II (MMP-II), one of the immuno-dominant antigens, in the serodiagnosis of leprosy was examined. The percent positivity by an enzyme-linked immunosorbent assay for anti-MMP-II antibody was 82.4% for multi-bacillary leprosy, and the specificity of the test was 90.1%. For pauci-bacillary leprosy where cell-mediated immunity predominates, 39.0% showed positive results. These percentage values were significantly higher than these values obtained for existing phenolic glycolipid-I based methods, suggesting that MMP-II antibody detection would facilitate the diagnosis of leprosy.</p>  a0378-1097