01506nas a2200253   4500000000100000008004100001260001300042653002300055653002600078653001700104653001100121653001200132653001500144653002200159653001600181100001400197700001400211700001300225245014300238300001100381490000700392520083900399022001401238       1975                            d  c1975 Nov10aHemoglobinopathies10aHemoglobins, Abnormal10aHeterozygote10aHumans10aleprosy10aMozambique10aSickle Cell Trait10aThalassemia1 aNowicki L1 aBehnken L1 aMartin H00a[Frequency of hemoglobin abnormalities and hemoglobinopathies in Mozambique peoples (comparison between leprosy and non-leprosy subjects].  a283-900 v313 a<p>In 588 bloodsamples of negride natives from Moçambique, preferably Chuabo and Macua, haemoglobin analyses were performed. In 21 cases an increase of Hb A2 was found, indicating the presence of heterozygous beta-thalassaemia, in one case the changes in Hb-analysis were typical for beta-delta-thalassaemia, 18 samples could be shown to contain Hb S, typical for the heterozygous sickle cell trait. Futhermore in 7 cases Hb A2' was found. In two bloodsamples haemoglobin variants were observed, which according to their electrophoretical mobility were assumed to represent Hb D in one case, and Hb G in the other. In the Chuabo population the frequency of the thalassaemia gene was found to be more than twice as high as in the Macua population. In non-lepers Hb S was observed with a remarkable higher incidence than in lepers.</p>  a0006-5242