02555nas a2200445   4500000000100000008004100001260001300042653001500055653001000070653000900080653002200089653002600111653002400137653001500161653001000176653002100186653001100207653001600218653001100234653002100245653001200266653000900278653001600287653002500303653001700328653003000345653000900375100001600384700001100400700001200411700001700423700001200440245009100452856005100543300001100594490000700605050003200612520145100644022001402095       2006                            d  c2006 Dec10aAdolescent10aAdult10aAged10aAged, 80 and over10aAntibodies, Bacterial10aAntigens, Bacterial10aBangladesh10aChild10aChild, Preschool10aFemale10aGlycolipids10aHumans10aImmunoglobulin M10aleprosy10aMale10aMiddle Aged10aMycobacterium leprae10aRisk Factors10aSeroepidemiologic Studies10aSkin1 aSchuring RP1 aMoet J1 aPahan D1 aRichardus JH1 aOskam L00aAssociation between anti-pGL-I IgM and clinical and demographic parameters in leprosy.  uhttps://leprosyreview.org/article/77/4/34-3355  a343-550 v77  aInfolep Library - available3 a<p><b>OBJECTIVE: </b>To determine the risk factors and clinical significance of anti-PGL-I seropositivity.</p><p><b>DESIGN: </b>A large-scale sero-epidemiological study (COLEP) was carried out in northwest Bangladesh. Blood on filter paper from 1025 newly diagnosed patients was collected before treatment was started and tested with an anti-PGL-I ELISA; the relation between patient determinants and seropositivity was calculated using logistic regression.</p><p><b>RESULTS: </b>The median age was 30 years and the male:female ratio 1.9. Overall, 342 patients (33.4%) were seropositive. The following determinants showed a significant correlation with seropositivity (P < 0-05) in multivariate analysis: sex, age, disability grade, bacterial index and classification according to the World Health Organization (WHO) system. The number and extent of clinical signs correlated with seropositivity, except for the presence of satellite lesions. People with or without a BCG vaccination scar had a similar risk to be seropositive.</p><p><b>CONCLUSION: </b>Serology is a marker for a higher systemic bacterial load and may identify potential infectious sources among patients with few clinical signs. The size of skin lesions was positively correlated with seropositivity. We did not find different levels of seropositivity among patients with one or two skin lesions, neither did we find different levels among patients with or without satellite</p>  a0305-7518