01607nas a2200265   4500000000100000008004100001260001700042653002600059653002100085653001100106653001200117653002500129653001900154100001100173700001300184700001000197700001200207700001200219245005400231300001000285490000700295050003200302520099300334022001401327       1990                            d  c1990 Jan-Mar10aAntibodies, Bacterial10aErythema Nodosum10aHumans10aleprosy10aLeprosy, lepromatous10aTetanus Toxoid1 aShwe T1 aThaung U1 aToe M1 aMya M M1 aMyint T00aThe effect of tetanus toxoid in leprosy patients.  a104-80 v62  aInfolep Library - available3 a<p>Since cases of lepra reaction following smallpox vaccination and BCG vaccination had been reported the effect of tetanus immunisation on leprosy patients (whether it may provoke a lepra reaction or not) was studied. Three doses of purified tetanus toxoid (one ml initially, one ml after six weeks and one ml after six months) were given to 357 leprosy patients and 60 patients living in the same environ were followed as controls. The antibody response following immunisation was followed in six lepromatous leprosy patients using toxin antitoxin neutralisation test at the Lf/1000 level in mice and in three of them the antibody titre of leprosy patients rose to satisfactory level. The number of lepra reactions in these patients was monitored for nine months (two months before vaccination, during the six months period of vaccination and one month after the last dose of vaccine). There was no significant rise in the number of patients with reaction following the vaccination.</p>  a0254-9395