01674nas a2200397   4500000000100000008004100001260001300042653004400055653003900099653002200138653001700160653001600177653002700193653001100220653003800231653001100269653002700280653003700307653001100344653002600355653002900381653002700410653002500437653001800462653001700480100001200497700001600509700001800525700001100543700001500554245010400569300001000673490000700683520057200690022001401262       1991                            d  c1991 Jun10aAntigens, Differentiation, T-Lymphocyte10aCandidiasis, Chronic Mucocutaneous10aCandidiasis, Oral10aCD2 Antigens10aCD3 Complex10aDisease Susceptibility10aFemale10aGenetic Predisposition to Disease10aHumans10aImmunocompromised Host10aImmunologic Deficiency Syndromes10aInfant10aLymphocyte Activation10aOpportunistic Infections10aReceptors, Immunologic10aT-Lymphocyte Subsets10aToxoplasmosis10aTuberculosis1 aNoh L M1 aHussein S H1 aSukumaran K D1 aRose I1 aAbdullah N00aChronic mucocutaneous candidiasis with deficient CD2 (E receptor) but normal CD3 mononuclear cells.  a89-930 v353 a<p>A case of chronic mucocutaneous candidiasis in a Malaysian child who subsequently developed disseminated tuberculosis and toxoplasmosis is described. The phenotype of her peripheral blood mononuclear cells showed discordance for her T cell markers. The presence of a subpopulation of CD2-/CD3+ mononuclear cells leading to an immunodeficiency state is consistent with failure of activation of CD2-mediated alternative pathway resulting in immunodeficiency. Such abnormal CD2-/CD3+ subpopulations have been described in lepromatous leprosy and foetal abortuses.</p>  a0141-2760