02393nas a2200397   4500000000100000008004100001260001300042653001200055653002400067653003800091653003100129653002000160653002000180653001100200653002100211653001400232653001200246653002400258653002500282653002500307653002500332653001500357653003000372653002700402100001400429700001600443700001800459700001600477700001400493245008300507856004100590300001000631490000700641520133300648022001401981       1997                            d  c1997 Jun10aAlleles10aAntigens, Bacterial10aGenetic Predisposition to Disease10aHistocompatibility Testing10aHLA-DQ Antigens10aHLA-DR Antigens10aHumans10aImmunity, Innate10aIndonesia10aleprosy10aLeprosy, Borderline10aLeprosy, lepromatous10aLeprosy, Tuberculoid10aMycobacterium leprae10aOdds Ratio10apolymerase chain reaction10aSequence Analysis, DNA1 aSoebono H1 aGiphart M J1 aSchreuder G M1 aKlatser P R1 aVries R R00aAssociations between HLA-DRB1 alleles and leprosy in an Indonesian population.  uhttp://ila.ilsl.br/pdfs/v65n2a05.pdf  a190-60 v653 a<p>To investigate whether the susceptibility to leprosy (type), subclinical infection with Mycobacterium leprae and the antibody response against M. leprae-specific antigens are associated with HLA-DR phenotypes sequence-specific oligonucleotide HLA-DRB1 and DQA1 typing and antibody assays have been performed in 79 leprosy patients (41 TT/BT and 38 LL/BL) and 50 healthy controls from a Javanese population in Yogyakarta, Indonesia. DRB1*02 was associated with LL/BL [odds ratio (OR) 2.54, 95% confidence interval (CI) 0.97-9.78, p = 0.037 and attributable risk (AR) 41.5%] but not with TT/BT leprosy (p > 0.05). HLA-DRB1*12 was negatively associated with leprosy (either LL/BL or TT/BT [OR 0.33-0.35, p < 0.05, prevented fraction (PF) 58.8%-65.3%]. No significant association was found between HLA-DRB1 or DQA1 type, anti-M. leprae antibody level and subclinical infection with M. leprae. These data indicate that in this population susceptibility to lepromatous leprosy is associated with HLA-DRB1*02, while resistance to leprosy is associated with HLA-DRB1*12. These associations are not paralleled with associations of the same HLA types with anti-M. leprae antibody level. Finally, the results of this study also support the notion that infection with M. leprae per se is not associated with HLA-DRB1 or DQA1 alleles.</p>  a0148-916X