02012nas a2200385   4500000000100000008004100001260001300042653001000055653002000065653001100085653001100096653001900107653001000126653002300136653001100159653002300170653001200193653000900205653001400214653004000228653000900268100001900277700001800296700001700314700002000331700001600351700001300367700001200380245022900392856007300621300001100694490000700705520090000712022001401612       2006                            d  c2006 Dec10aAdult10aAnti-HIV Agents10aBrazil10aFemale10aHIV Infections10aHIV-110aHistocytochemistry10aHumans10aLeprostatic Agents10aleprosy10aMale10aPregnancy10aPregnancy Complications, Infectious10aSkin1 aTrindade M A B1 aValente N Y S1 aManini M I P1 aTakahashi M D F1 aAnjos C F D1 aBenard G1 aNaafs B00aTwo patients coinfected with Mycobacterium leprae and human immunodeficiency virus type 1 and naive for antiretroviral therapy who exhibited type 1 leprosy reactions mimicking the immune reconstitution inflammatory syndrome.  uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1698401/pdf/1425-06.pdf  a4616-80 v443 a<p>Two case reports of patients with human immunodeficiency virus type 1 (HIV-1) infection who developed leprosy are presented. Both developed type 1 leprosy reactions in the absence of antiretroviral therapy. Reactions have been described for a number of HIV-1- and Mycobacterium leprae-coinfected patients and have been considered to be part of an immune reconstitution inflammatory syndrome (IRIS) since the reactions were usually linked to the administration of highly active antiretroviral therapy. The reports of our two patients suggest that the type 1 reactions in patients with leprosy and HIV may not always be an IRIS manifestation but may be akin to the classical reactional state described for the natural course of leprosy infection, which occurs in leprosy patients due to the fluctuations of the antimycobacterial immune response, whether they are coinfected with HIV or not.</p>  a0095-1137