01670nas a2200397   4500000000100000008004100001260000900042653001800051653001000069653003700079653002100116653001600137653002700153653001600180653002300196653001700219653001100236653001100247653001200258653000900270653002500279653000900304653002300313653002900336653002700365653002200392653003900414653001700453100001500470245005400485300000900539490000700548050001500555520068800570022001401258       1975                            d  c197510aAcute disease10aAdult10aAutonomic Fibers, Postganglionic10aBody Temperature10aDenervation10aDysautonomia, Familial10aExtremities10aFacial Hemiatrophy10aFacial Nerve10aFemale10aHumans10aleprosy10aMale10aMycobacterium leprae10aNeck10aNerve Degeneration10aNerve Fibers, Myelinated10aNeuromuscular Diseases10aPeripheral nerves10aPeripheral Nervous System Diseases10aSense Organs1 aBrowne S G00aLeoprosy- clinical aspectos of nerve involvement.  a1-160 v12  aBROWNE19753 a<p>Leprosy is the cause of the commonest peripheral neuropathy. The predilection of Mycobacterium leprae for nerve tissue accounts for the clinical features that are most dreaded and most characteristic of the disease. Were it not for the progressive destruction of peripheral nerve trunks and the consequences of this, leprosy would largely remain a cutaneous condition of cosmetically unsightly hypopigmented or erythematous areas and aggregations of nodular thickenings. The neurologic damage in leprosy is confined to postganglionic changes. The central nervous system is protected, although rarely in experimental situations organisms have been reported in cerebral tissues.</p>  a0069-9446