01481nas a2200337   4500000000100000008004100001260001700042653001200059653001600071653001800087653001200105653002200117653003000139653002300169653001200192653000900204653003200213653002500245653001400270653001300284653001500297100001500312700001800327700001600345245008500361300001100446490000700457050003200464520063300496022001401129       1991                            d  c1991 Apr-Jun10aAnimals10aClofazimine10aCulture Media10aDapsone10aDrug Interactions10aDrug Therapy, Combination10aLeprostatic Agents10aleprosy10aMice10aMicrobial Sensitivity Tests10aMycobacterium leprae10aRifabutin10aRifampin10aRifamycins1 aDhople A M1 aLamoureux L C1 aGardner G D00aIn vitro and in vivo interactions of drugs used in multidrug therapy in leprosy.  a166-790 v63  aInfolep Library - available3 a<p>Interactions of different drugs commonly used in multiple drug therapy were evaluated using both in vitro culture (cell-free as well as macrophage) system and mouse footpad. No additive effects were obtained in the in vitro system when dapsone was combined with either rifampicin or clofazimine, while a strong antagonism was observed when clofazimine was combined with rifampicin but not with rifabutin. In the mouse footpad system, a strong synergism was obtained when clofazimine was combined with either rifampicin or rifabutin, but significant antagonism was observed with the combination of clofazimine and dapsone.</p>  a0254-9395