01709nas a2200361   4500000000100000008004100001260001600042653002300058653001700081653003100098653001700129653001600146653001100162653002100173653001800194653001700212653001200229653001600241653002500257653001800282100001400300700001500314700001700329700001600346700001300362700001500375700001400390245009200404300001100496490000800507520081800515022001401333       1991                            d  c1991 Oct 1110aAntibody Formation10aCD4 Antigens10aCD4-Positive T-Lymphocytes10aCD8 Antigens10aClone Cells10aHumans10aInterferon-gamma10aInterleukin-410aInterleukins10aleprosy10aLymphokines10aT-Lymphocyte Subsets10aT-Lymphocytes1 aSalgame P1 aAbrams J S1 aClayberger C1 aGoldstein H1 aConvit J1 aModlin R L1 aBloom B R00aDiffering lymphokine profiles of functional subsets of human CD4 and CD8 T cell clones.  a279-820 v2543 a<p>Functional subsets of human T cells were delineated by analyzing patterns of lymphokines produced by clones from individuals with leprosy and by T cell clones of known function. CD4 clones from individuals with strong cell-mediated immunity produced predominantly interferon-gamma, whereas those clones that enhanced antibody formation produced interleukin-4. CD8 cytotoxic T cells secreted interferon-gamma. Interleukin-4 was produced by CD8 T suppressor clones from immunologically unresponsive individuals with leprosy and was found to be necessary for suppression in vitro. Both the classic reciprocal relation between antibody formation and cell-mediated immunity and resistance or susceptibility to certain infections may be explained by T cell subsets differing in patterns of lymphokine production.</p>  a0036-8075