01358nas a2200253   4500000000100000008004100001260001300042653001200055653002600067653001800093653001500111653002100126653001200147653000900159653002500168653001500193100001500208245008300223856004100306300001000347490000700357520072600364022001401090       1991                            d  c1991 Dec10aAnimals10aAnti-Infective Agents10aCiprofloxacin10aFleroxacin10aFluoroquinolones10aleprosy10aMice10aMycobacterium leprae10aQuinolones1 aPattyn S R00aAnti-Mycobacterium leprae activity of several quinolones studied in the mouse.  uhttp://ila.ilsl.br/pdfs/v59n4a10.pdf  a613-70 v593 a<p>The anti-Mycobacterium leprae activity of several fluoroquinolones (A-56619, A-56620, ofloxacin, fleroxacin, lomefloxacin, temafloxacin, tosufloxacin, and PD-117596) was studied in the mouse. In a dosage of 150 mg/kg administered daily, A-56619 is active and A-56620 is inactive against M. leprae. Ofloxacin administered daily for 2 weeks at 300 mg/kg is bactericidal. The minimal effective dose of PD-117596, lomefloxacin and temafloxacin is less than 37.5 mg/kg. When administered at 300 mg/kg at monthly intervals temafloxacin, PD-117596, and ofloxacin are bacteriostatic; while fleroxacin and lomefloxacin are bactericidal. Tosufloxacin is less active than the other quinolones included in the present study.</p>
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