01641nas a2200385   4500000000100000008004100001260001300042653001200055653001800067653001400085653002300099653001200122653001900134653002300153653003000176653001700206653002100223653002200244653001600266653000900282653002500291653004400316653001600360100001300376700001300389700001200402700001200414700001300426245006600439856007600505300001100581490000800592520064100600022001401241       2006                            d  c2006 Jun10aAnimals10aBase Sequence10aCell Line10aCloning, Molecular10aCosmids10aDNA, Bacterial10aDNA, Complementary10aGene Expression Profiling10aGene Library10aGenes, Bacterial10aGenome, Bacterial10aMacrophages10aMice10aMycobacterium leprae10aOligonucleotide Array Sequence Analysis10aPseudogenes1 aSuzuki K1 aNakata N1 aBang PD1 aIshii N1 aMakino M00aHigh-level expression of pseudogenes in Mycobacterium leprae.  uhttp://onlinelibrary.wiley.com/doi/10.1111/j.1574-6968.2006.00276.x/pdf  a208-140 v2593 a<p>Recent studies have revealed that some RNAs are transcribed from noncoding DNA regions, including pseudogenes, and are functional as riboregulators. We have attempted to assess the gene expression profile throughout the Mycobacterium leprae genome using an array technique. Twelve highly expressed gene regions were identified that show an alteration in expression levels upon infection. Six of these were pseudogenes. Although M. leprae has an exceptional number and proportion of pseudogenes among species, our results suggest that some of the M. leprae pseudogenes are not just 'decayed' genes, but may have a functional role.</p>  a0378-1097