01711nas a2200421   4500000000100000008004100001260001300042653001500055653001000070653001200080653000900092653002300101653001100124653001100135653001300146653001100159653001000170653001200180653000900192653000900201653001500210653001600225653002500241653003600266653003900302653001700341100001500358700001700373700001500390700001100405700001100416245014300427856007600570300001000646490000800656520061100664022001401275       2006                            d  c2006 Aug10aAdolescent10aAdult10aAnimals10aAsia10aBacterial Proteins10aBrazil10aFemale10agenotype10aHumans10aJapan10aleprosy10aMale10aMice10aMice, Nude10aMiddle Aged10aMycobacterium leprae10aPolymorphism, Single Nucleotide10aRepetitive Sequences, Nucleic Acid10aSigma Factor1 aMatsuoka M1 aLopez Roa RI1 aBudiawan T1 aKyaw K1 aChae G00aGenotypic analysis of Mycobacterium leprae isolates from Japan and other Asian countries reveals a global transmission pattern of leprosy.  uhttp://onlinelibrary.wiley.com/doi/10.1111/j.1574-6968.2006.00346.x/pdf  a150-40 v2613 a<p>The genotype of single-nucleotide polymorphism type 3, CTC, at positions 14676, 164275, and 2935685, along with four copies of 6 bp repeats in the rpoT gene, was predominant for isolates originating in the Japanese mainland. Type 1, CGA, type 2, CTA, and type 3 were detected from Korea, Indonesia, and Myanmar. No isolates with four copies of 6 bp were detected from Myanmar, Okinawa, and Japanese Brazilian patients. Type 4, TTC, with three copies of 6 bp, was detected only from Japanese Brazilians. The results indicate that infection occurred in Brazil and the disease developed later in Japan.</p>  a0378-1097