01173nas a2200289   4500000000100000008004100001260001300042653001200055653002600067653001700093653001900110653001700129653001200146653000900158653002400167653002500191653001800216100001500234700001000249700001200259700001500271245009600286300001000382490000700392520047000399022001400869       1991                            d  c1991 Apr10aAnimals10aAnti-Bacterial Agents10aAzithromycin10aClarithromycin10aErythromycin10aleprosy10aMice10aMice, Inbred BALB C10aMycobacterium leprae10aRoxithromycin1 aGelber R H1 aSiu P1 aTsang M1 aMurray L P00aActivities of various macrolide antibiotics against Mycobacterium leprae infection in mice.  a760-30 v353 a<p>We evaluated the activities of several macrolide antibiotics against M. leprae infections in mouse footpads. Erythromycin and azithromycin were inactive, while both roxithromycin and clarithromycin were found to be consistently active and, in fact, bactericidal. By both methods, clarithromycin was found to be superior to roxithromycin, a finding which, at least in part, may be a consequence of the higher levels of clarithromycin at the site of infection.</p>  a0066-4804