01219nas a2200241   4500000000100000008004100001260001300042653002500055653003800080653001800118653001100136653001200147653001800159653001700177100001600194700001400210245006300224300001100287490000700298050001800305520064000323022001400963       2006                            d  c2006 Apr10aCase-Control Studies10aGenetic Predisposition to Disease10aGenome, Human10aHumans10aleprosy10aMycobacterium10aTuberculosis1 aFernando SL1 aBritton W00aGenetic susceptibility to mycobacterial disease in humans.  a125-370 v84  aFERNANDO 20063 a<p>Mycobacterial disease remains a serious global health problem. Tuberculosis causes more than 2 million deaths a year, and leprosy is still a cause of severe disability in many parts of the world. As a result of the study of individuals with marked susceptibility to usually nonpathogenic mycobacteria, as well as case-control studies with candidate genes and genome-wide screens of affected populations, there is substantial evidence for the role of genetic factors in the susceptibility to mycobacterial disease. These studies have defined immunological processes essential for the control of mycobacteria infections in humans.</p>  a0818-9641