02325nas a2200481   4500000000100000008004100001260001300042653001500055653001000070653000900080653002200089653001100111653001000122653001300132653001100145653001100156653001000167653001200177653002400189653002500213653002500238653000900263653001600272653001300288653001700301653001500318653002600333653000900359653001700368653002200385100001600407700001800423700001600441700001500457700001600472245008600488856004100574300000900615490000700624050001700631520118100648022001401829       1993                            d  c1993 Mar10aAdolescent10aAdult10aAged10aAged, 80 and over10aBiopsy10aChild10aErythema10aFemale10aHumans10aIndia10aleprosy10aLeprosy, Borderline10aLeprosy, lepromatous10aLeprosy, Tuberculoid10aMale10aMiddle Aged10aNeuritis10aPrednisolone10aRecurrence10aRetrospective Studies10aSkin10aTime Factors10aTreatment Outcome1 aLockwood DN1 aVinayakumar S1 aStanley J N1 aMcAdam K P1 aColston M J00aClinical features and outcome of reversal (type 1) reactions in Hyderabad, India.  uhttp://ila.ilsl.br/pdfs/v61n1a02.pdf  a8-150 v61  aLOCKWOOD19933 a<p>A retrospective survey of the notes on all patients attending Dhoolpet Leprosy Research Center, India, during 1985 was done to establish the frequency, timing, and clinical features of reversal (type 1) reactions; 494 case notes were examined and clinical evidence of a reversal reaction was found in 44 cases (10.9%). Reactions were most common in borderline patients, with 11.4% and 14.8% of borderline tuberculoid (BT) and borderline lepromatous (BL) patients developing reactions, respectively. Presentation in reaction was frequent with 47.5% of reactional patients having signs of a reversal reaction at the time of their first visit to the Dhoolpet clinic; 50% of skin reactions developing in patients on antileprosy treatment occur within the first month of treatment. Neurological reactions occur later and over a longer time course. Late reactions may occur up to 6 1/2 years after the start of treatment. Further reactional episodes occurred in 31.8% of the patients, and may be repeated. Steroid treatment produced improvement of both skin lesions and neuritis, but improvement in clinical signs and symptoms occurred in only 50% of the neuritic episodes.</p>
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