01432nas a2200289   4500000000100000008004100001260001300042653001200055653002000067653002400087653002000111653001200131653001900143653000900162653002400171653001700195653001800212100001300230700001400243700001600257245010400273856007800377300001200455490000700467520065400474022001401128       1992                            d  c1992 Aug10aAnimals10aCells, Cultured10aHeat-Shock Proteins10aHot Temperature10aleprosy10aMacaca mulatta10aMice10aMice, Inbred BALB C10aPhagocytosis10aSchwann Cells1 aMistry Y1 aYoung D B1 aMukherjee R00ahsp70 synthesis in Schwann cells in response to heat shock and infection with Mycobacterium leprae.  uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC257288/pdf/iai00032-0089.pdf  a3105-100 v603 a<p>Induction of heat shock protein synthesis was monitored in murine and monkey Schwann cells exposed to elevated temperatures. Synthesis of the stress-inducible 70-kDa heat shock protein (hsp70) was detected in both murine and primate Schwann cells by metabolic labelling and by immunoblotting with a specific monoclonal antibody. hsp70 synthesis was also induced in Schwann cells after infection with Mycobacterium leprae and was detected from 24 h to 1 week postinfection. These results are discussed with respect to the possible role of heat shock proteins in immunopathological events associated with the clinical manifestations of leprosy.</p>  a0019-9567