01721nas a2200337   4500000000100000008004100001260001300042653001500055653001000070653002100080653000900101653002200110653001200132653001600144653001100160653001000171653001100181653002000192653001200212653001900224653001300243653001600256653001500272653001700287100001300304245004400317300000900361490000700370520099200377022001401369       1994                            d  c1994 Jun10aAdolescent10aAdult10aAge Distribution10aAged10aAged, 80 and over10aAmyloid10aAmyloidosis10aBiopsy10aChild10aHumans10aKidney Diseases10aleprosy10aLiver Diseases10aMalaysia10aMiddle Aged10aPrevalence10aTuberculosis1 aLooi L M00aThe pattern of amyloidosis in Malaysia.  a11-30 v163 a<p>Congo red screening of routine biopsies at the University Hospital Kuala Lumpur revealed the following categories of amyloidosis: systemic AL (5.9%); systemic AA (3.2%); isolated atrial (14%); primary localized cutaneous (7.5%); other primary localized deposits (3.2%); localized intratumour (58%); and dystrophic (8.6%). Unlike in the West, AA amyloidosis in this population was usually secondary to leprosy or tuberculosis. Liver involvement in AL amyloidosis was shown to exhibit a sinusoidal pattern and differed from the vascular pattern of AA amyloidosis. Within the category of AA amyloidosis, there were two patterns of renal involvement--glomerular and vascular, with the glomerular pattern carrying a more ominous clinical picture. Notable among the localized amyloidoses were isolated atrial amyloidosis complicating chronic rheumatic heart disease, intratumour amyloidosis within nasopharyngeal carcinomas and dystrophic amyloidosis which occurred in fibrotic tissues.</p>  a0126-8635