01663nas a2200313   4500000000100000008004100001260001300042653002300055653001100078653003000089653001100119653002300130653001200153653002700165653002200192653003900214653001400253653000900267100001400276700001300290700001200303700001500315245007400330300001100404490000800415050001700423520089500440022001401335       2005                            d  c2005 Oct10aBacterial Vaccines10aBiopsy10aDrug Therapy, Combination10aHumans10aLeprostatic Agents10aleprosy10aNeurologic Examination10aPeripheral nerves10aPeripheral Nervous System Diseases10aPrognosis10aSkin1 aAgrawal A1 aPandit L1 aDalal M1 aShetty J P00aNeurological manifestations of Hansen's disease and their management.  a445-540 v107  aAGRAWAL 20053 a<p>Hansen's disease is almost eliminated from developed countries but in developing countries of Africa, Asia and Latin America leprosy is still considered to be a public health problem. Mycobacterium leprae have the affinity for peripheral nerves and neuropathy is a cardinal manifestation of the disease. The nerve damage affects sensory, motor, and autonomic fibers resulting in the physical impairments and limitation of physical activities and social participation. Leprosy is a curable disease and treatment provided in the early stages will avert the disabilities. Approach to the neuritic leprosy depends on its clinical characteristics, nerve biopsy, and histological appearance of dermatological and neurological lesions. In this article we review the literature and discuss the pathology, clinical features, diagnosis and management of neurological manifestations of leprosy.</p>  a0303-8467