02819nas a2200565   4500000000100000008004100001260001300042653001200055653001000067653004200077653001900119653002200138653001500160653002700175653001100202653001200213653001800225653001900243653001800262653001900280653001900299653001100318653002700329653002300356653002900379653001200408653002300420653000900443653001600452653001500468653002600483653003000509653002900539100001400568700001300582700001200595700001200607700001500619700001200634700001000646700001900656700001400675700001200689700001500701245015400716300001100870490000700881520135100888022001402239       2005                            d  c2005 Sep10aAbscess10aAdult10aAntiretroviral Therapy, Highly Active10aCohort Studies10aCutaneous Fistula10aDermatitis10aDisease Susceptibility10aFemale10aFistula10aFrench Guiana10aHerpes Simplex10aHerpes Zoster10aHistoplasmosis10aHIV Infections10aHumans10aImmunocompromised Host10aImmunologic Memory10aLeishmaniasis, Cutaneous10aleprosy10aLymphatic Diseases10aMale10aMiddle Aged10aRecurrence10aRetrospective Studies10aSkin Diseases, Infectious10aTuberculosis, Lymph Node1 aSarazin E1 aNacher M1 aToure Y1 aClyti E1 aEl Guedj M1 aAznar C1 aVaz T1 aSainte-Marie D1 aSobesky M1 aCarme B1 aCouppié P00a[Dermatologic manifestations associated with immune reconstitution syndrome in HIV+ patients starting HAART: a retrospective study in French Guiana].  a187-920 v983 a<p>Immune reconstitution syndrome (IRIS) is an unusual inflammatory reaction to an opportunistic infection in an HIV-positive patient. This syndrome occurs when immunity is restored in the first months of an effective highly active antiretroviral treatment (HAART). First, we described all patients with a cutaneous form of IRIS. Then, between 1992 and 2004 we conducted a retrospective cohort study comparing Herpes Zoster and Herpes Simplex infections among untreated patients, patients treated by HAART for < or = six months, and patients treated for > six months. We observed three cases of atypical leprosy and three original observations: two of these were fistulisation of lymph node histoplasmosis and tuberculosis, the third one reports the recurrence of a treated cutaneous leishmaniasis. Multivariate analysis showed that, after controlling for age, sex and CD4 counts, patients receiving HAART for < or = six months were more likely to develop Herpes Zoster or herpes simplex infections (p < 0.005). Herpes Simplex and Herpes Zoster infections are the two most frequent dermatological manifestations in our tropical setting. Although mycobacterial infections are more rarely observed than in visceral IRIS, the increased incidence of leprosy may be quite significant when the availability of HAART spreads to developing countries.</p>  a0037-9085