01398nas a2200325   4500000000100000008004100001260001600042653001200058653001200070653002900082653003700111653003100148653001100179653002300190653001200213653000900225653002300234653002500257653001500282100001300297700001700310700001600327700000900343700001400352245011400366300001100480490000700491520056000498022001401058       2006                            d  c2006 Jan 1510aAnimals10aDapsone10aDihydropteroate Synthase10aDose-Response Relationship, Drug10aDrug Resistance, Bacterial10aHumans10aLeprostatic Agents10aleprosy10aMice10aMutation, Missense10aMycobacterium leprae10aRecurrence1 aCambau E1 aCarthagena L1 aChauffour A1 aJi B1 aJarlier V00aDihydropteroate synthase mutations in the folP1 gene predict dapsone resistance in relapsed cases of leprosy.  a238-410 v423 a<p>Molecular detection was compared with the mouse footpad inoculation test for detection of dapsone resistance in 38 strains of Mycobacterium leprae. Mutations of the folP1 gene (at codons 53 or 55) were found in 6 of 6 strains with high-level resistance, in 3 of 4 strains with intermediate-level resistance, and in 1 of 6 strains with low-level resistance, but not in 22 dapsone-susceptible strains. In cases of infection with strains of M. leprae carrying the folP1 mutation, therapy with dapsone may be replaced by therapy with a fluoroquinolone.</p>  a1537-6591