01690nas a2200325   4500000000100000008004100001260001300042653001500055653001000070653001600080653002500096653002800121653001000149653002500159653001100184653001100195653001000206653001200216653000900228653002600237653001500263653001700278100001700295700001500312245013900327300001000466490000800476520086600484022001401350       1999                            d  c1999 Nov10aAdolescent10aAdult10aBCG Vaccine10aCase-Control Studies10aChi-Square Distribution10aChild10aConfidence Intervals10aFemale10aHumans10aIndia10aleprosy10aMale10aMatched-Pair Analysis10aOdds Ratio10aSocial Class1 aKulkarni H R1 aZodpey S P00aDifferential protective effect of bacillus Calmette-Guerin vaccine against multibacillary and paucibacillary leprosy in Nagpur, India.  a311-30 v1133 a<p>For this paper we conducted a secondary data analysis to test the hypothesis that a linear trend exists in the protective effect of bacillus Calmette-Guerin (BCG) vaccine against types of leprosy. We used data from two previous case-control studies to perform an unmatched test for linear trend. We observed that both the studies revealed a significant linear trend (P<0.00001). One study that estimated an insignificant protective effect of BCG against paucibacillary leprosy showed a significant departure from linearity. We conclude that, the protective effect of BCG vaccination is differential across severity of leprosy as it brings about a shift in the immune response to a higher level of cell mediated immunity. We recommend that future studies dealing with the protective effect of BCG against leprosy should also conduct an analysis for trend.</p>  a0033-3506