02646nas a2200433   4500000000100000008004100001260001700042653001000059653001000069653001900079653003000098653001100128653001100139653001000150653002300160653001200183653002000195653000900215653001600224653002600240653002500266653001400291653001500305653002600320653001300346653002100359100001300380700001500393700001800408700002000426700001500446700001600461245007600477300001100553490000700564050003200571520159500603022001402198       2005                            d  c2005 Apr-Jun10aAdult10aChild10aCohort Studies10aDrug Therapy, Combination10aFemale10aHumans10aIndia10aLeprostatic Agents10aleprosy10aLogistic Models10aMale10aMinocycline10aMultivariate Analysis10aMycobacterium leprae10aOfloxacin10aRecurrence10aRetrospective Studies10aRifampin10aRural Population1 aAli SM K1 aThorat D M1 aSubramanian M1 aParthasarathy G1 aSelvaraj U1 aPrabhakar V00aA study on trend of relapse in leprosy and factors influencing relapse.  a105-150 v77  aInfolep Library - available3 a<p>A retrospective analysis of data pertaining to the rural field operation area of the Central Leprosy Teaching and Research Institute, Chengalpattu, Tamil Nadu, was carried out to determine the magnitude of relapse after MDT and its significance with other variables. The study included 3248 leprosy patients who have successfully completed treatment during 1987-2003, of whom 2892 were PB and 356 MB cases. A total of 58 cases of relapse was reported which gives a crude cumulative relapse rate of 1.78% for the 16-year period of follow-up and the rates for PB and MB were 1.9% and 0.84% respectively. With respect to PB cases, 68% of relapses were reported in the first 3 years of RFT. The person-year relapse rate was highly significant with regard to the number of skin lesions (p<0.0002) and nerve involvement (p<0.0002). The person-year relapse rate did not differ significantly between PB and MB leprosy, male and female, and child and adult cases. RFT year cohort relapse rate reveals that the introduction of MB-MDT regimen for PB leprosy had resulted in the reduction of relapses among PB cases after 1998. The relapse rate with reference to the time gap after RFT reveals that relapse declines with passage of time after RFT. The risk of relapse was very low in both PB and MB leprosy which fact emphasizes that proper counselling about signs and symptoms of relapse during RFT is adequate to combat the problem. A majority of relapses occurred in the first three years after RFT. The number of skin lesions and involvement of nerves were the main risk factors for relapse.</p>  a0254-9395