02725nas a2200517   4500000000100000008004100001260001300042653001500055653001000070653000900080653001700089653002800106653001500134653001100149653002800160653001500188653001300203653002500216653002500241653002800266653002700294653001100321653002800332653001200360653000900372653001600381653003000397653001500427653001700442653001500459653001800474653002200492653001100514100001300525700001800538700001200556700001200568700001200580700001800592700001500610245017900625300001000804490000700814520137200821022001402193       2005                            d  c2005 Aug10aAdolescent10aAdult10aAged10aBlood Donors10aCircoviridae Infections10aDNA, Viral10aFemale10aFlaviviridae Infections10aGB virus C10agenotype10aHepatitis B, Chronic10aHepatitis C, Chronic10aHepatitis, Viral, Human10aHospitals, Psychiatric10aHumans10aIntellectual Disability10aleprosy10aMale10aMiddle Aged10apolymerase chain reaction10aPrevalence10aRisk Factors10aRNA, Viral10aSchizophrenia10aTorque teno virus10aTurkey1 aKalkan A1 aOzdarendeli A1 aBulut Y1 aSaral Y1 aOzden M1 aKeleştimur N1 aToraman ZA00aPrevalence and genotypic distribution of hepatitis GB-C/HG and TT viruses in blood donors, mentally retarded children and four groups of patients in eastern Anatolia, Turkey.  a222-70 v583 a<p>We investigated the prevalence and genotypic distribution of GB virus-C/hepatitis G virus (GBV-C/HGV) and TT virus (TTV) in blood donors, mentally retarded children and four groups of patients living in Eastern Anatolia, Turkey. The prevalence and genetic analysis of TTV were determined by using the primers of the UTR and ORF1 regions of TTV, respectively. Reverse transcription nested (RT-n)-PCR was used to amplify 5' UTR of GBV-C/HGV. Genotyping of HGV was carried out by PCR-based genotyping assay while RFLP was conducted to determine the genotypes of TTV. TTV DNA was detected in 118 of 410 sera tested, giving an overall prevalence of 28.7%; GBV-C/HGV-RNA was detected in only 17 cases, giving an overall prevalence of 4.1%. No significant differences were observed in the number of positive or negative tests for GBV-C/HGV and TTV according to duration of illness or mean duration of institutionalization in any of the groups studied. Although all samples from the study population belonged to genotypes 1 and 4, the most common TTV genotype is G2. In conclusion, our results indicate a low endemicity of GBV-C/HGV and TTV infection in Eastern Anatolia, Turkey. The presence of G2 strains reveals the limited genetic diversity of the GBV-C/HGV circulating in Turkey. We suggest that TTV infection of genotypes 1 and 4 is prevalent in the same region.</p>  a1344-6304