01355nas a2200349   4500000000100000008004100001260001300042653000900055653001600064653001200080653003000092653001000122653000900132653001100141653002300152653001200175653003100187653000900218653002300227653001300250653001400263653002200277100001500299700001500314700001400329700002600343245008000369300000900449490000700458520052600465022001400991       2006                            d  c2006 Feb10aAged10aClofazimine10aDapsone10aDrug Therapy, Combination10aEdema10aFoot10aHumans10aLeprostatic Agents10aleprosy10aMagnetic Resonance Imaging10aMale10aMethylprednisolone10aRifampin10aSynovitis10aTreatment Outcome1 aHelling CA1 aLocursio A1 aManzur ME1 aSormani de Fonseca ML00aRemitting seronegative symmetrical synovitis with pitting edema in leprosy.  a95-70 v253 a<p>A 67-year-old man, who had widespread and well-defined erythematous violaceous hyperkeratotic plaques on his skin, was diagnosed with borderline tuberculoid leprosy. The patient began treatment with clofazimine, rifampicin, and dapsone, but 15 days afterwards he complained of acral edema with godet sign. Magnetic resonance imaging was done, and the case was interpreted as remitting seronegative symmetrical synovitis with pitting edema. About 8 mg/day of methylprednisolone were started with excellent response.</p>  a0770-3198