01673nas a2200313   4500000000100000008004100001260001300042653001000055653000800065653001100073653001200084653002600096653003500122653001600157653000900173653001600182653001500198653001100213653001800224100001200242700001400254700001300268700001200281245008400293300001000377490000700387520095100394022001401345       1979                            d  c1979 Jun10aAdult10aDNA10aHumans10aleprosy10aLymphocyte Activation10aLymphocyte Culture Test, Mixed10aLymphopenia10aMale10aMiddle Aged10aMitomycins10aPlasma10aT-Lymphocytes1 aHan S H1 aChang Z N1 aTsai L C1 aHsu K H00aFactors contributing to impairment of the mixed lymphocyte reaction in leprosy.  a35-420 v123 a<p>Whereas the mixed lymphocyte reaction was essentially normal in inactive lepromatous leprosy and tuberculoid leprosy, it was severely impaired in active lepromatous leprosy. The impairment was found to be contributed by certain unknown factors in their plasma and subnormal reactivity of their T lymphocytes. The plasma derived from active lepromatous leprosy patients depressed the reaction of normal cells and normal plasma enhanced the reaction of active lepromatous lymphocytes. The cellular factor was studied by using a one-way reaction in which one of the two lymphocyte preparations was inactivated with mitomycin C. The impairment of blastogenesis of active lepromatous lymphocytes was partially reversed by substituting inactivated normal cells for similarly treated leprous cells, and conversely the response of normal allogeneic lymphocytes was depressed by substituting inactivated leprous lymphocytes as the stimulator cells.</p>  a0009-4587