01181nas a2200229   4500000000100000008004100001260001600042653001100058653001200069100001700081700001600098700001200114700002300126700001600149700001500165700001300180245004100193300001100234490000700245520068500252022001400937       1992                            d  c1992 Mar 0110aHumans10aleprosy1 aGrossetete G1 aSonneck J M1 aKeita S1 aPointies-le-Roux B1 aLeGuyadec T1 aBeaulieu P1 aMillet P00a[Leprosy. Developmental modalities].  a606-120 v423 a<p>The very broad clinical spectrum of the Mycobacterium leprae infection is due to the diversity of the underlying immunological and genetic factors. The evolutive modalities of leprosy are mainly determined by a dual pathogenesis: An infectious disease due to a bacillus of low virulence which, even when dead, persists in the body for several years, independently of the antibiotic therapy prescribed. A dysimmune disease maintained by a chronic discharge of antigens. Neuropathies and leprous reactions are still the most troublesome episodes in the course of the disease. They constitute the principal prognostic factor in both pauci- and multibacillary forms of leprosy.</p>  a0035-2640