01195nas a2200265   4500000000100000008004100001260001300042653001100055653001400066653001100080653002500091653001600116653001200132653000900144653001600153100001500169700001400184700001400198700001400212245012300226300001100349490000800360520054700368022001400915       1992                            d  c1992 Apr10aBiopsy10aFerritins10aHumans10aImmunohistochemistry10aLactoferrin10aleprosy10aSkin10aTransferrin1 aMomotani E1 aWuscher N1 aRavisse P1 aRastogi N00aImmunohistochemical identification of ferritin, lactoferrin and transferrin in leprosy lesions of human skin biopsies.  a213-200 v1063 a<p>Granulomatous lesions of human leprosy contained ferritin and lactoferrin but little or no transferrin, as demonstrated by the avidin-biotin complex immunoperoxidase method. Lactoferrin was found in the neutrophils. These results suggested that the cells of the host mononuclear phagocyte system in leprosy granulomas provide an adequate nutritional environment for iron acquisition by M. leprae. A possible role of iron binding proteins in the granulomas is discussed in relation to previous data on bovine paratuberculous granulomas.</p>  a0021-9975