01157nas a2200229   4500000000100000008004100001260001700042653001200059653002300071653002900094653001100123653001200134653002400146653002500170653001600195100001800211700001900229245004300248300001100291520061100302022001400913       2005                            d  c2005 Mar-Apr10aAnimals10aBacterial Vaccines10aClinical Trials as Topic10aHumans10aleprosy10aMycobacterium bovis10aMycobacterium leprae10aVaccination1 aKalianina O V1 aIushchenko A A00a[Development of antileprosy vaccines].  a93-1003 a<p>The absence of an effective antileprosy vaccine, capable of preventing the spread of leprosy hinders its control in endemic countries. Developing such a vaccine is highly difficult due to the absence of reproducible methods for the in vitro cultivation of Mycobacterium leprae. The results of field trials of earlier proposed vaccines (BCG and BCG in combination with killed M. leprae) are indicative of their insufficient efficacy. The article presents a review of literature, including historical information, current problems and the main approaches to the development of vaccine against leprosy.</p>  a0372-9311