01291nas a2200337   4500000000100000008004100001260001300042653002400055653001000079653001600089653001200105653002600117653003000143653001100173653001100184653002300195653001200218653001300230653001300243100002300256700001500279700001300294700001500307700001500322245008500337300000900422490000600431050002400437520047800461022001400939       2005                            d  c2005 Feb10aAcute Kidney Injury10aAdult10aClofazimine10aDapsone10aDrug Hypersensitivity10aDrug Therapy, Combination10aFemale10aHumans10aLeprostatic Agents10aleprosy10aRifampin10aSyndrome1 aAlves-Rodrigues EN1 aRibeiro LC1 aSilva MD1 aTakiuchi A1 aFontes CJF00aDapsone syndrome with acute renal failure during leprosy treatment: case report.  a84-60 v9  aALVESRODRIGUES 20053 a<p>Dapsone syndrome is a rare hypersensitivity reaction to dapsone and is characterized by high fever, papular or exfoliative dermatitis, progressing to liver toxicity and generalized lymphadenopathy, resembling a mononucleosis infection. We report a patient who developed acute renal failure, as well as other complications characteristic of dapsone syndrome, during leprosy treatment. Renal involvement had not been previously described as a dapsone syndrome feature.</p>  a1413-8670