01342nas a2200301   4500000000100000008004100001260001300042653001800055653001900073653001100092653002100103653001300124653001200137653002600149653001600175653001800191653002200209653003000231100001200261700001400273700001500287700001400302245006400316300001100380490000800391520062700399022001401026       1979                            d  c1979 Oct10aCell Adhesion10aConcanavalin A10aHumans10aImmunoglobulin G10aLepromin10aleprosy10aLymphocyte Activation10aLymphocytes10aReceptors, Fc10aRosette Formation10aT-Lymphocytes, Regulatory1 aMehra V1 aMason L H1 aFields J P1 aBloom B R00aLepromin-induced suppressor cells in patients with leprosy.  a1813-70 v1233 a<p>The possibility of an active mechanism of immunologic suppression in leprosy was explored by assessing the in vitro lymphocyte responses of 61 leprosy patients and 30 normal individuals to the mitogen Con A in the presence or absence of Dharmendra lepromin. Lepromin-induced suppression of Con A stimulation was found in 32 of 35 lepromatous patients and 15 of 15 borderline patients, but only 2 of 15 tuberculoid patients and 2 of 30 normal controls. Cell fractionation studies indicated at least two cell populations involved in the in vitro lepromin-induced suppressor activity, adherent cells and T gamma-cells.</p>  a0022-1767