01703nas a2200301   4500000000100000008004100001260001700042653001200059653001500071653001800086653001200104653000900116653002500125653002500150653001800175653001700193653002300210653001800233653001800251100001400269700001400283245007000297300001000367490000700377050003200384520097100416022001401387       1992                            d  c1992 Jan-Mar10aAnimals10aCell Count10aCell Division10aleprosy10aMice10aMicroscopy, Electron10aMycobacterium leprae10aMyelin Sheath10aNerve Fibers10aNerve Regeneration10aSchwann Cells10aSciatic Nerve1 aRasouli I1 aMehta L N00aReaction of peripheral nerves to vascular and bacterial injuries.  a14-270 v64  aInfolep Library - available3 a<p>Mouse sciatic nerves were subjected to devascularization, M. leprae inoculation, and combined insult of devascularization + footpad inoculation (FPI). Changes were seen in FPI nerves only after eight months, but in cases of combined insult, changes were evident in hours. Both the groups showed initial loss of small myelinated fibres. No proliferation of Schwann cells was in FPI nerves, but in combined insult it was maximum after two weeks. Presence of M. leprae seems to be arresting Schwann cell activity after two weeks. Blood vessels showed increased endothelial cell cytoplasm, basement membrane proliferation and villi formation. These changes seem to be specific of endoneurial blood vessels of leprosy nerves. Increased number of mast cells seems to be specific of devascularized and FPI nerves. Increased number of macrophages expressed low immunity of devascularized nerves. Eosinophils migrated to endoneurium as a result of leakage of axoplasm.</p>  a0254-9395