01057nas a2200313   4500000000100000008004100001260001300042653002800055653002900083653001900112653002100131653001100152653002900163653002500192653000900217653001700226653001600243653001700259653002200276653002200298100001100320700001100331245003500342856004100377300001000418490000700428520029400435022001400729       2004                            d  c2004 Dec10aAdrenal Cortex Hormones10aAnti-Inflammatory Agents10aDrug Synergism10aErythema Nodosum10aHumans10aImmunosuppressive Agents10aLeprosy, lepromatous10aMale10aMethotrexate10aMiddle Aged10aPrednisolone10aTreatment Failure10aTreatment Outcome1 aKar BR1 aBabu R00aMethotrexate in resistant ENL.  uhttp://ila.ilsl.br/pdfs/v72n4a08.pdf  a480-20 v723 a<p>This is a report of a case of steroid resistant severe Type 2 reaction that was managed with methotrexate and prednisolone. Synergistic action of both the drugs in severe Type 2 reaction make them one of the preferred combinations in the absence of other agents such as thalidomide.</p>  a0148-916X