02050nas a2200361   4500000000100000008004100001260001300042653001000055653000900065653002600074653002400100653003800124653002200162653001600184653001100200653001200211653000900223653001600232653002500248100002000273700001400293700001300307700001400320700001200334700001600346245017200362856005900534300000900593490000700602050003200609520103300641022001401674       1992                            d  c1992 Mar10aAdult10aAged10aAntibodies, Bacterial10aAntigens, Bacterial10aEnzyme-Linked Immunosorbent Assay10aFollow-Up Studies10aGlycolipids10aHumans10aleprosy10aMale10aMiddle Aged10aMycobacterium leprae1 aChin-a-Lien R A1 aFaber W R1 aRens M M1 aLeiker DL1 aNaafs B1 aKlatser P R00aFollow-up of multibacillary leprosy patients using a phenolic glycolipid-I-based ELISA. Do increasing ELISA-values after discontinuation of treatment indicate relapse?  uhttp://leprev.ilsl.br/pdfs/1992/v63n1/pdf/v63n1a04.pdf  a21-70 v63  aInfolep Library - available3 a<p>With the introduction of reproducible serological tests it was hoped that relapses in leprosy patients, after discontinuing treatment, could be detected before damaging reactions occurred and before the patients became infectious. The possible value of an ELISA using a semisynthetic analogue of phenolic glycolipid-I to detect antibodies to this antigen in order to predict a relapse in multibacillary patients was investigated. In contrast to that reported for paucibacillary patients, this test was useful to detect early relapses in multibacillary patients. In 3 out of 4 multibacillary patients who relapsed, the ELISA-values were increased. The decreased ELISA-values in the one relapsed patient could be attributed to the corticosteroid therapy. In the multibacillary patients who did not relapse after RFT, the ELISA-values were consistently low or decreased. In only one patient did the ELISA-values increase following his release from treatment and this patient was clinically suspected of developing a relapse.</p>  a0305-7518