01409nas a2200253   4500000000100000008004100001260001300042653001600055653001200071653003000083653001600113653001100129653002300140653001200163100001500175700001500190245008800205856005900293300001000352490000700362050003200369520074000401022001401141       1992                            d  c1992 Mar10aClofazimine10aDapsone10aDrug Therapy, Combination10aEthionamide10aHumans10aLeprostatic Agents10aleprosy1 aPattyn S R1 aBourland J00aAmbulatory treatment of multibacillary leprosy with a regimen of 8 months duration.  uhttp://leprev.ilsl.br/pdfs/1992/v63n1/pdf/v63n1a06.pdf  a36-400 v63  aInfolep Library - available3 a<p>An ambulatory treatment regimen for multibacillary leprosy, of 34 weeks duration composed of 8 weeks daily supervised rifampicin, ethionamide (ETH), dapsone (DDS) and clofazimine (CLO) followed by 26 weeks of unsupervised ETH, DDS and CLO, introduced in 1983 has been evaluated; 268 patients were followed for a mean of 4.4 years and a total of 1188 patient years. The relapse rate was 0.33 per 100 patient years of follow up. The reduction of the duration of the combined administration of RMP + ETH reduced the hepatotoxicity to 1.4%. It is possible that both phases of the regimen studied could still be reduced, however, in the near future ETH will be replaced by alternative bactericidal drugs, avoiding the hepatotoxicity.</p>  a0305-7518