01687nas a2200361   4500000000100000008004100001260001300042653001300055653001800068653002500086653003800111653002200149653001100171653002500182653002700207653002800234653002600262653003000288653002800318653002500346653002400371653001500395100001500410700001300425700001600438700001400454245005500468300001000523490000800533050001800541520075200559022001401311       2005                            d  c2005 Apr10aArginine10aBase Sequence10aCase-Control Studies10aGenetic Predisposition to Disease10aGenetic Variation10aHumans10aLeprosy, lepromatous10aMembrane Glycoproteins10aMolecular Sequence Data10aPolymorphism, Genetic10aPromoter Regions, Genetic10aReceptors, Cell Surface10aToll-Like Receptor 210aToll-Like Receptors10aTryptophan1 aMalhotra D1 aRelhan V1 aReddy B S N1 aBamezai R00aTLR2 Arg677Trp polymorphism in leprosy: revisited.  a413-50 v116  aMALHOTRA 20053 a<p>We investigated the Toll-like receptor 2 (TLR2) Arg677Trp polymorphism, associated with lepromatous leprosy in the Korean population and shown to abrogate TLR2-mediated signalling in response to mycobacterial ligands, in 286 Indian leprosy patients and 183 ethnically matched controls. The case-control comparison also involved investigation of possible variation(s) in the promoter region of the TLR2 gene. Genotyping results after direct PCR sequencing showed that the TLR2 Arg677Trp polymorphism associated with lepromatous leprosy in the Korean population is not a true polymorphism of the TLR2 gene and has resulted from the variation present in the 93% homologous duplicated region of TLR2 exon 3 present approximately 23 kb upstream.</p>  a0340-6717