02929nas a2200529   4500000000100000008004100001260001600042653001000058653000900068653002500077653001800102653001400120653002000134653002000154653002700174653001100201653004100212653001100253653002500264653001100289653002100300653000900321653001600330653001400346653002500360653003100385653003100416653002500447653001400472653001700486100001500503700001700518700001400535700001200549700001400561700001000575700001500585700001500600700001600615700001400631245016100645856006100806300001200867490000800879520149800887022001402385       2005                            d  c2005 Mar 0110aAdult10aAged10aAntigen Presentation10aAntigens, CD110aCell Line10aCells, Cultured10aDendritic Cells10aEpitopes, T-Lymphocyte10aFemale10aHistocompatibility Antigens Class II10aHumans10aLeprosy, lepromatous10aLipids10aLymphocyte Count10aMale10aMiddle Aged10aMonocytes10aMycobacterium leprae10aMycobacterium tuberculosis10aReceptors, Antigen, T-Cell10aT-Lymphocyte Subsets10aTh2 Cells10aTuberculosis1 aSieling PA1 aTorrelles JB1 aStenger S1 aChung W1 aBurdick A1 aRea T1 aBrennan PJ1 aBelisle JT1 aPorcelli SA1 aModlin RL00aThe human CD1-restricted T cell repertoire is limited to cross-reactive antigens: implications for host responses against immunologically related pathogens.  uhttp://www.jimmunol.org/content/174/5/2637.full.pdf+html  a2637-440 v1743 a<p>The repertoires of CD1- and MHC-restricted T cells are complementary, permitting the immune recognition of both lipid and peptide Ags, respectively. To compare the breadth of the CD1-restricted and MHC-restricted T cell repertoires, we evaluated T cell responses against lipid and peptide Ags of mycobacteria in leprosy, comparing tuberculoid patients, who are able to restrict the pathogen, and lepromatous patients, who have disseminated infection. The striking finding was that in lepromatous leprosy, T cells did not efficiently recognize lipid Ags from the leprosy pathogen, Mycobacterium leprae, or the related species, Mycobacterium tuberculosis, yet were able to efficiently recognize peptide Ags from M. tuberculosis, but not M. leprae. To identify a mechanism for T cell unresponsiveness against mycobacterial lipid Ags in lepromatous patients, we used T cell clones to probe the species specificity of the Ags recognized. We found that the majority of M. leprae-reactive CD1-restricted T cell clones (92%) were cross-reactive for multiple mycobacterial species, whereas the majority of M. leprae-reactive MHC-restricted T cells were species specific (66%), with a limited number of T cell clones cross-reactive (34%) with M. tuberculosis. In comparison with the MHC class II-restricted T cell repertoire, the CD1-restricted T cell repertoire is limited to recognition of cross-reactive Ags, imparting a distinct role in the host response to immunologically related pathogens.</p>  a0022-1767