01054nas a2200229   4500000000100000008004100001260001300042653002400055653001800079653001200097653002900109653003100138653002300169653001300192653002500205100001000230245011900240300001000359490000700369520043400376022001400810       2004                            d  c2004 Sep10aAmino Acid Sequence10aBase Sequence10aDapsone10aDihydropteroate Synthase10aDrug Resistance, Bacterial10aLeprostatic Agents10aMutation10aMycobacterium leprae1 aKai M00a[Diaminodiphenylsulfone resistance of Mycobacterium leprae due to mutations in the dihydropteroate synthase gene].  a221-60 v733 a<p>The relation between diaminodiphenylsulfone (called dapsone)-resistance and point mutations of the dihydropteroate synthase (DHPS) gene was analyzed using dapsone resistant Mycobacterium leprae isolates derived from Japanese leprosy patients. The mutation was found at amino acid residues 53 or 55 of the DHPS. This finding suggests that two specific mutations in the DHPS gene involved in dapsone resistance of M. leprae.</p>  a1342-3681