01255nas a2200289   4500000000100000008004100001260001300042653001200055653001800067653001200085653001500097653003300112653003000145653001100175653002300186653001200209653001300221653002500234653001400259653001300273100001200286245007600298300001100374490000700385520055900392022001400951       2004                            d  c2004 Sep10aAnimals10aBase Sequence10aDapsone10aDNA gyrase10aDNA-Directed RNA Polymerases10aDrug Resistance, Multiple10aHumans10aLeprostatic Agents10aleprosy10aMutation10aMycobacterium leprae10aOfloxacin10aRifampin1 aMaeda S00a[Multi-drug resistant Mycobacterium leprae from patients with leprosy].  a227-330 v733 a<p>DNA sequences of Mycobacterium leprae in particular regions of the gyrA, rpoB, and folP genes responsible for resistance to new quinolones, rifampicin and dapsone, respectively, were analyzed. Among 88 isolates of M. leprae from leprosy patients in Japan, Haiti, Indonesia, Pakistan, and the Philippines, eleven isolates had mutational changes in 2 genes (resistance to 2 drugs), and 2 isolates (Shinsei-1 and Zensho-4) showed mutations in 3 genes (resistance to 3 drugs). These findings are suggesting emergence of multi-drug resistant M. leprae.</p>  a1342-3681