01444nas a2200265   4500000000100000008004100001260001300042653003100055653002000086653003800106653001100144653001200155653002500167653002200192653001300214653003000227100001500257700001400272245006800286856004100354300001100395490000700406520075100413022001401164       2004                            d  c2004 Jun10aChromosomes, Human, Pair 610aGenetic Linkage10aGenetic Predisposition to Disease10aHumans10aleprosy10aMolecular Chaperones10aParkinson Disease10aProteins10aUbiquitin-Protein Ligases1 aBuschman E1 aSkamene E00aLinkage of leprosy susceptibility to Parkinson's disease genes.  uhttp://ila.ilsl.br/pdfs/v72n2a09.pdf  a169-700 v723 a<p>In early 2003, an international team of scientists conducted a genome scan in Vietnamese multiplex leprosy families and found that susceptibility to leprosy was significantly linked to region q25 on the long arm of chromosome 6. Further confirmation of the chromosome 6 locus was provided by high-resolution linkage mapping in simplex leprosy families. Now, in a continuation of these findings, the team has pinpointed the chromosome 6 susceptibility locus to the 5' regulatory promoter region shared by both the Parkinson's disease gene PARK2 and its co-regulated gene PACRG. The surprising discovery has important implications for the understanding of leprosy pathogenesis and for the strategy of genetic analysis of infectious diseases.</p>  a0148-916X